Identification of subclinical cardiac amyloidosis in aortic stenosis patients undergoing transaortic valve replacement using radiomic analysis of computed tomography myocardial texture.

Clinical presentation associated to cardiac amyloidosis (CA) shows an increased biventricular wall thickness, myocardial stiffening and ventricles restrictive physiology caused by amyloid myocardial deposition. 1 Bonelli A. Paris S. Nardi M. et al. Aortic valve stenosis and cardiac amyloidosis: a misleading association. J Clin Med. 2021; 10: 4234 Crossref PubMed Scopus (5) Google Scholar Similar myocardial remodeling processes affect patients with aortic stenosis (AS), that is the most common cause of valvular heart disease. 2 Elmariah S. Patterns of left ventricular remodeling in aortic stenosis: therapeutic implications. Curr Treat Options Cardiovasc Med. 2015; 17: 31 Crossref Scopus (12) Google Scholar As CA shares several common phenotypical features with AS and considering the high prevalence of subclinical CA among AS undergoing transcatheter aortic valve implantation (TAVI), the differential diagnosis of these two entities has important prognostic and therapeutic implications.