Screening for Latent Tuberculosis Infection in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.

Daniel E Jonas,Sean R Riley,Lindsey C Lee,Cory P Coffey,Shu-Hua Wang,Gary N Asher,Anne M Berry, Niketa Williams,Casey Balio,Christiane E Voisin,Leila C Kahwati

JAMA（2023）

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摘要

No studies directly evaluated the benefits and harms of screening for LTBI compared with no screening. TST and IGRAs were moderately sensitive and highly specific. Treatment of LTBI with recommended regimens reduced the risk of progression to active tuberculosis. Isoniazid was associated with higher rates of hepatotoxicity than placebo or rifampin.

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