Effect of Total SMS (Sphingomyelin Synthase) Activity on LDL (Low-Density Lipoprotein) Catabolism in Mice.

Zhiqiang Li,Mulin He,Guangzhi Chen, Tade Souaiaia,Tilla S Worgall,Xian-Cheng Jiang

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

Whole-body SM biosynthesis plays an important role in LDL cholesterol catabolism. The total SMS deficiency, but not SMS2 deficiency, reduces LDL uptake and causes LDL cholesterol accumulation in the circulation. Given the fact that serum SM level is a risk factor for cardiovascular diseases, inhibiting SMS2 but not SMS1 should be the desirable approach.

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