Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.

Yuhong Qin, Yani Shi, Qi Yu,Shenglan Yang,Ying Wang, Xiaojia Dai,Guoxing Li,Zhe Cheng

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie（2023）

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摘要

High doses of vitamin B12 supplements improved myocardial I/R injury by suppressing the accumulation of reactive oxygen species and apoptosis of myocardial tissue through modulation of the SIRT3/AMPK signaling pathway, while reducing inflammation. Our findings suggested that vitamin B12 administered at high doses could be a potential therapy for myocardial I/R damage.

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Myocardial ischemia/reperfusion injury,Vitamin B12,SIRT3,AMPK

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