Effects of combined application of fibroblast growth factor (FGF)-2 and carbonate apatite for tissue regeneration in a beagle dog model of one-wall periodontal defect.

This study demonstrated that the combination of FGF-2 and COAp was effective not only in enhancing new bone formation and replacing scaffold but also in maintaining the existing bone adjacent to the defect site in a beagle dog model of one-wall periodontal defect. Additionally, new periodontal tissues induced by FGF-2 and COAp may follow a maturation process similar to that formed by spontaneous healing. This suggests that the combined use of FGF-2 and COAp would promote periodontal regeneration in severe bony defects of periodontitis patient.