Factors Associated with Tuberculosis Relapses Development

The objective: to identify socio-demographic, clinical and laboratory factors associated with tuberculosis recurrence.Subjects and Methods. Clinical and laboratory data of 208 TB patients treated at the National Scientific Center for Phthisiopulmonology of the Ministry of Health of the Republic of Kazakhstan were analyzed.IL-2 to the AlaDH was assessed using test platforms Lionex GmbH (Germany) according to the manufacturer's instructions. SPSS 23.0 software was used for statistical processing of obtained data. To assess the significance of differences in groups, the Pearson Chi-Square test was used. To determine the factors associated with of the tuberculosis relapse, а multiple binary logistic regression analysis was carried out.Results. Multivariate logistic regression analysis confirmed that male gender (OR = 2.086, 95% CI 1.001-4.350, p = 0.050), drug resistance (OR = 4.910, 95% CI 1.923-12.534, p = 0.001), fibrosis cavernous tuberculosis (OR = 6.362, 95% CI 2.178-18.585, p = 0.001) and low level of sensitized T cells that synthesize IL-2 in response to exposure to the AlaDH antigen in IGRA in vitro (OR = 2.155, 95% CI 1.060-4.379, p = 0.034) were significantly associated with tuberculosis recurrence.