Camouflaging multifunctional nanoparticles with bacterial outer membrane for augmented chemodynamic/photothermal/starvation/chemo multimodal synergistic therapy of orthotopic glioblastoma

Chemical Engineering Journal(2023)

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摘要
•Integration of the advantages with multiple therapeutic approaches to a single nano-medicine.•Enhanced blood–brain barrier penetration by bacterial outer membrane vesicles camouflage.•Augmented chemodynamic therapy by photothermal effect and H2O2 supplement.•Controlled drug release by photothermal/pH in the tumor environment.•Reversing the thermotolerance of cancer cells by GOx induced down-regulation of heat shock protein.
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关键词
glioblastoma,multifunctional nanoparticles,bacterial outer membrane,augmented chemodynamic/photothermal/starvation/chemo
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