Evaluation of the physicochemical quality and antimicrobial performance of amoxicillin and amoxicillin + clavulanic acid discs used in Burkina Faso

Djibril Diallo,B. Gérard Josias Yaméogo, Ouéogo Nikiema,Mohamed Belem,W. Bertrand Goumbri,Belinda Moné Bassavé,Abdoul-Salam Ouédraogo,Elie Kabré,Rasmané Semdé

Results in Chemistry（2023）

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摘要

•Twenty samples of amoxicillin and amoxicillin + clavulanic acid discs were collected.•HPLC-DAD method was validated for assay of amoxicillin and clavulanic acid in discs.•Susceptibility test was assessed by EUCAST diffusion method on reference strains.•40% of samples failed antimicrobial performance and active substance assay tests.•All disc samples had non-compliant clavulanic acid content.

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antimicrobial performance,amoxicillin,clavulanic acid discs,physicochemical quality

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