Developing And Characterizing An Osteochondral-Synovial Model For Evaluating Psoriatic Arthritis Therapies

Purpose: The overall purpose of this study is to develop and characterize a human osteochondral-synovial model for evaluating psoriatic arthritis (PsA) therapies. Two aims of the study; Aim 1: Establish and optimize a local end-stage PsA-like model based on a validated human OA model. Aim 2: Preliminary validation of the local end-stage PsA-like model by adding dexamethasone (DEX), a known anti-inflammatory drug, to the co-culture.