Radiotherapy for Ledderhose disease: Results of the LedRad-study, a prospective multicentre randomised double-blind phase 3 trial

•First randomised controlled trial to investigate the efficacy of radiotherapy for Ledderhose disease.•Radiotherapy for Ledderhose disease results in pain reduction in majority of patients.•Quality of life improves after radiotherapy for Ledderhose disease and is comparable to the reference population.•Side effects after radiotherapy for Ledderhose disease are limited.•The most demanding walking situation for patients with Ledderhose disease, barefoot speed walking, significantly improves after radiotherapy.