The regulatory roles of Fasciola hepatica GSTO1 protein in inflammatory cytokine expression and apoptosis in murine macrophages

Wang Xifeng,Zhang Jiahua,Li Ningxing,Zhang Guowu,Shang Yunxia,Cai Xuepeng,Qiao Jun,Xia Xianzhu,Meng Qingling

Acta Tropica（2023）

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摘要

•F. hepatica recombinant GSTO1 protein exhibited potent resistance to oxidative damage.•F. hepatica recombinant GSTO1 protein could induce apoptosis in murine macrophage RAW264.7.•F. hepatica recombinant GSTO1 protein suppressed LPS-induced NF-κB and MAPK pathway (p38, ERK, JNK) activation in murine macrophage RAW264.7.

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fasciola hepatica gsto1 protein,macrophages,inflammatory cytokine expression,apoptosis

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