Immune microenvironment and prognosis of tongue squamous cell carcinomas

Objective To characterize immune cells in the tumor microenvironment of Tongue Squamous Cell Carcinoma (TSCC) and to evaluate its prognostic significance. Study Design forty-eight cases of TSCC were selected. Immunohistochemical reactions were carried out against CD3, CD4, CD8, CD20, CD68, CD1a, CD83, PD-1, and PD-L1; the analysis was performed to investigate the relation between the type of immune cells and clinical characteristics, such as tumor size, presence of local and distant metastasis, and overall survival. Results Analysis revealed that high expression CD3, CD8, CD20, and CD83 were statistically significant when associated with an improvement in overall survival rate. Conclusion Evidence to support the values higher of tumor-infiltrating lymphocytes (TILs) and mature dendritic cells (DC) are correlated with improvements in overall survival in TSCC patients, influenced by characteristics and behaviors of tumor and prognosis. To characterize immune cells in the tumor microenvironment of Tongue Squamous Cell Carcinoma (TSCC) and to evaluate its prognostic significance. forty-eight cases of TSCC were selected. Immunohistochemical reactions were carried out against CD3, CD4, CD8, CD20, CD68, CD1a, CD83, PD-1, and PD-L1; the analysis was performed to investigate the relation between the type of immune cells and clinical characteristics, such as tumor size, presence of local and distant metastasis, and overall survival. Analysis revealed that high expression CD3, CD8, CD20, and CD83 were statistically significant when associated with an improvement in overall survival rate. Evidence to support the values higher of tumor-infiltrating lymphocytes (TILs) and mature dendritic cells (DC) are correlated with improvements in overall survival in TSCC patients, influenced by characteristics and behaviors of tumor and prognosis.