Relationship of HPV16 E6 seropositivity with circulating tumor tissue modified HPV DNA before head and neck cancer diagnosis

Eleni M. Rettig,Tim Waterboer, Edward S. Sim,Daniel L. Faden,Glenn J. Hanna,Catherine Del Vecchio Fitz,Charlotte Kuperwasser,Herve Sroussi

CLINICAL CANCER RESEARCH（2023）

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摘要

•HPV-positive OPC biomarkers were compared in blood collected before OPC diagnosis.•HPV16 E6 seropositivity was more common than plasma tumor tissue-modified HPV16 DNA.•E6 seroconversion likely occurs before plasma TTMV-HPV16 DNA is detectable.

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关键词

hpv16 e6 seropositivity,hpv16 dna,neck cancer,tumor tissue

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