Higher serum uric acid is associated with body fat, retinol-binding protein 4, and antioxidative status in Brazilian children

Objective: The aim of this study was to evaluate the association of serum uric acid (SUA) with adiposity, adi-pokines, and anti-and oxidative markers in Brazilian children.Methods: This was a cross-sectional investigation with 378 children ages 8 to 9 yin Vi,cosa, Minas Gerais, Bra-zil. Information on sociodemographic and lifestyle characteristics was obtained via questionnaires, and body fat was determined by dual energy x-ray absorptiometry. We compared the distributions of adiposity (total and central), adipokines (adiponectin, chemerin, leptin, and retinol-binding protein 4 [RBP4]), anti-and oxi-dative markers (plasma ferric reducing antioxidant power [FRAP], superoxide dismutase [SOD], and malon-dialdehyde [MDA]) by SUA categories using linear regression.Results: SUA was positively associated with total and central fat. Every standard deviation (SD) of SUA was related, respectively, to a 3.4 (95% confidence interval [CI], 2.4-4.4), 4 (95% CI, 2.8-5.1), 4.2 (95% CI, 2.9-5.5), and 3.5 (95% CI, 2.4-4.6) units higher of total, truncal, android, and gynoid fat. We found a positive associa-tion of SUA with RBP4 and FRAP, and a negative association with MDA. Every SD of SUA was related, respec-tively, to 0.1 (95% CI, 0.01-0.1) and 7.8 (95% CI, 5.5-10.1) units higher of RBP4 and FRAP; and to-0.3 (95% CI,-0.5 to-0.1) units lower of MDA.Conclusions: SUA was positively associated with adiposity, RBP4, and antioxidative status in Brazilian chil-dren.& COPY; 2023 Elsevier Inc. All rights reserved.