Wcn23-0472 understanding the mechanism of sglt2 inhibitor in young persons with type 2 diabetes using single-cell rna-seq data

ALAKWAA F., Schaub J., McCown P.,Naik A., Eddy S., Nair V.,Pyle L., Hodgin J.,Brosius F., Nelson R.,Kretzler M.,Bjornstad P.

Kidney International Reports（2023）

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摘要

Youth-onset type 2 diabetes (T2D) carries a higher risk of diabetic kidney disease (DKD) than type 1 and adult-onset type 2 diabetes of similar duration, with few treatment options. SGLT2 inhibitors (SGLT2i) are protective against DKD, but the mechanisms of nephroprotection are incompletely understood.

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关键词

sglt2 inhibitor,diabetes,single-cell,rna-seq

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