Locomotion and brain gene expression exhibit sex-specific non-monotonic dose-response to HFPO-DA during Drosophila melanogaster lifespan

Jeanne P. Vu,Flannery McLamb,Zuying Feng,Lindsey Griffin,Sylvia Gong,Damian Shea,Mary A. Szuch,Savannah Scott,Richard M. Gersberg,Goran Bozinovic

NeuroToxicology（2023）

引用 0|浏览5

暂无评分

摘要

•Low BCF values indicate that HFPO-DA does not readily bioaccumulate in flies.•Lifespan was significantly reduced starting at 102 mg/kg/day in both sexes.•Exposure-induced locomotion score decline was more evident in females than males.•Brain gene expression patterns are specific to sex and exposure duration.

查看译文

关键词

HFPO-DA,Brain,Gene expression,Locomotion,Lifespan

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要