Oxidative Stress-mediated Sprouty-related Protein with an EVH1 Domain 1 Down-regulation Contributes to Resisting Oxidative Injury in Microglia

Li Wei,Xin Li,Qianfeng Wei,Lin Chen,Li Xu,Peng Zhou

Neuroscience（2023）

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摘要

•Down-regulation of SPRED1 expression was induced by cerebral ischemia–reperfusion.•Oxidative stress exhibited a fluctuating regulatory effect on SPRED1 level in BV2 microglia.•Oxidative stress enhances the induction to p65 upon SPRED1 over-expression in BV2 microglia.•Oxidative stress-mediated SPRED down-regulation contributes to resisting oxidative injury in microglia.

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关键词

microglia,evh1 domain,resisting oxidative injury,stress-mediated,sprouty-related,down-regulation

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