A new COF@AuNC catalytic amplification-aptamer SERS quantitative analysis method for trace estradiol with nanoreaction of HAuCl4-sulfite

•A new solvothermal procedure was used to prepare COFloaded gold nanocluster (AuCOF).•The AuCOF catalysis and stability were improved by loaded gold nanoclusters onto the COF.•The AuCOF catalyzed strongly the new nanogold indicator reaction of Au(III)-SO32− with SERS and RRS effects.•A new Apt SERS quantitative method for the rapid determination of estradiol.