CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes

Chaithanya P. Vedula,Neil J. Ganem

Molecular Cell（2023）

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摘要

Lin et al. demonstrate that acentric chromosome fragments generated within micronuclei are tethered by the CIP2A-TOPBP1 complex during mitosis, thus promoting clustered segregation of the fragments to a single daughter cell nucleus and facilitating re-ligation with limited chromosomal scattering and loss.

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molecular lassos,topbp1

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