CCL19+ dendritic cells potentiate clinical benefit of anti-PD-(L)1 immunotherapy in triple-negative breast cancer

Song-Yang Wu,Si-Wei Zhang,Ding Ma,Yi Xiao,Yin Liu,Li Chen,Xiao-Qing Song,Xiao-Yan Ma,Ying Xu,Wen-Jun Chai,Xi Jin,Zhi-Ming Shao,Yi-Zhou Jiang

Med（2023）

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摘要

•Single-cell profiling of DCs in breast tumors from retrospective clinical trials•CCL19+ DCs are associated with TLS/LA presence and ICI-responsive immune contexture•DC-derived CCL19 mediates CCR7+CD8+ T cells to synergize with PD-1 blockade in TNBC•Circulating and intratumoral CCL19 predicts improved clinical benefit of PD-1 blockade

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dendritic cells,triple-negative triple-negative breast cancer,breast cancer

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