Ultrasound technology and biomaterials for precise drug therapy

Advanced ultrasound technology and functional biomaterials can be used to achieve precision drug therapy in different aspects such as dose, space, and/or time. This review first introduces the classification of ultrasound and related physical properties involving precision drug treatment, and then systematically discusses the realization of drug precision treatment through sonophoresis and sonopermeation. In particular, key information such as effective ultrasonic intensity and frequency parameter range, types of loaded drugs, systematic therapeutic effect, and so on for precision therapy with an advanced combination of ultrasonic technology and various biological materials were expounded and summarized. In addition, relevant clinical opportunities and challenges are described. Finally, the development and application prospects of ultrasound-functional biomaterials for drug precision therapy are prospected.