Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation

Meihui Tao,Wei Yan,Chaoyue Chen,Mengfan Tang,Xi Zhao,Qinyu Feng,Xiaoshang Fei,Yu Fu

Life Sciences（2023）

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摘要

Omentin-1 activates the Nrf2 pathway to regulate redox balance, ultimately protecting intestinal barrier function and reducing intestinal inflammation. In general, Omentin-1 can be used as a promising therapeutic target for IBD.

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关键词

Omentin-1, Acute colitis, Intestinal barrier function, Nrf2 signaling, NF-& kappa,B pathways, Redox regulation

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