Gap26 inhibited angiogenesis through the β-catenin-VE-cadherin-VEGFR2-Erk signaling pathway

Chuyang Xu,Wei Zhong,Hong Zhang,Jinlan Jiang,Hongyan Zhou

Life Sciences（2023）

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摘要

Gap26 can downregulate VEGFR2 phosphorylation by stabilizing the expression of β-catenin and VE-cadherin on the cell membrane, thereby inhibiting VEGFA-induced HUVECs proliferation, migration and tube formation and inhibiting corneal neovascularization.

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关键词

angiogenesis,catenin-ve-cadherin-vegfr

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