First prospective observational data on pregnancies in patients with primary Sjögren's syndrome.

Sjögren's syndrome is a systemic autoimmune disease that predominantly occurs in women and affects exocrine glands, particularly the salivary and lacrimal glands, resulting in severe dryness of mucosal surfaces. The autoantibody profile associated with primary Sjögren's syndrome varies between patients but most commonly includes antinuclear antibodies, anti-Ro/SSA antibodies, anti-La/SSB antibodies, and rheumatoid factor; numerous other autoantibodies, such as anti-CCP, anti-RNP, and antiphospholipid antibodies might also be found in these patients. The presence of anti-Ro/SSA and anti-La/SSB antibodies is associated with neonatal lupus erythematosus and congenital heart block in a titre-dependent manner, and is therefore highly relevant to women who are planning to conceive. 1 Sammaritano LR Bermas BL Chakravarty EE et al. 2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases. Arthritis Care Res (Hoboken). 2020; 72: 461-488 Crossref PubMed Scopus (84) Google Scholar Attention to Sjögren's syndrome-related antibodies in the setting of reproductive health care has focused on their association with serious complications in babies born to mothers who have anti-SSA or anti-SSB antibodies. Little is known to date about pregnancy outcomes and risk of disease flares in pregnant women with primary Sjögren's syndrome. This disease is most frequently diagnosed in women aged 30–50 years, 2 Brito-Zerón P Baldini C Bootsma H et al. Sjögren syndrome. Nat Rev Dis Primers. 2016; 216047 Crossref PubMed Scopus (404) Google Scholar but as the obstetric population is shifting to older ages, and given the advances made in assisted reproduction techniques, more children might be born to mothers with primary Sjögren's syndrome in the future. Pregnancy outcomes in women with primary Sjögren's syndrome: an analysis of data from the multicentre, prospective, GR2 studyPregnancies in women with primary Sjögren's syndrome had very good prognoses for mothers and fetuses, with no overall increase in adverse pregnancy outcome risk compared with the general population. Women with antiphospholipid antibodies or anti-RNP antibodies require close monitoring, because these factors might be associated with a higher risk of adverse pregnancy outcomes. Full-Text PDF