Comparison of the Pharmacokinetic and Pharmacodynamic profiles of epinephrine delivered by a sublingually absorbed film (DESF), versus 0.3 mg administered by a standard IM injection or the EpiPen®

Greenhawt Matthew,John Oppenheimer,David Golden,Carlos Camargo,David Fleischer,David Bernstein,Jay Lieberman,Mark Freedman,Gary Slatko,Steve Wargacki

Journal of Allergy and Clinical Immunology（2023）

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摘要

DESF is being developed for the treatment of anaphylaxis as an alternative to injectable epinephrine. This study compared the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of epinephrine following single-dose administration of (12 mg) DESF vs. 0.3mg IM injection and EpiPen® 0.3mg.

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关键词

epinephrine,pharmacokinetic,pharmacodynamic profiles,standard im injection

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