New drug-like small molecule antagonizes phosphatidylinositol (3,4,5)-trisphosphate (PIP3) in patients with conotruncal heart defects

Alaaeldin G. Fayez,Nora N. Esmaiel,Engy A. Ashaat,Miral M. Refeat, Randa S. Lotfy,Haiam Abdel Raouf,Mona O. El Ruby

Journal of Taibah University Medical Sciences（2023）

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摘要

PIP3 is a useful diagnostic biomarker for patients with CTDs. The Akt-pharmacophore feature model is a feasible approach for discovery of PIP3 signalling antagonists. Further 322PESB development and testing are recommended.

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关键词

Akt, Conotruncal heart defects, Drug design, PIP3 antagonist, Pleckstrin homology domain, Signal transduction pathway

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