Temporal patterns and distribution of pyroptosis-related molecules and effects of human mesenchymal stem cells on pyroptosis following cerebral ischemia/reperfusion in rats

Kuang Pan,Qingxia Peng, Zejia Huang,Zhaofei Dong,Weijye Lin,Yidong Wang

Journal of Stroke and Cerebrovascular Diseases（2023）

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摘要

In the early stage of cerebral infarction in rats, there were dynamic changes in pyroptosis-related molecules (caspase-1 and GSDMD), but MSCs showed no effect on the levels of GSDMD or neurological function.

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关键词

Caspase,Cerebral ischemia/reperfusion,Gasdermin,Mesenchymal stem cells,Middle cerebral artery occlusion (MCAO),Pyroptosis

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