Proangiogenic Growth Factor Therapy for the Treatment of Refractory Angina: A Meta-analysis

Deshan Weeraman,Daniel A. Jones,Mohsin Hussain,Anne-Marie Beirne, Steven Hadyanto,Krishnaraj S. Rathod,James R. Whiteford,Alice E. Reid,Christos V. Bourantas,Seppo Ylä-Herttuala,Andreas Baumbach,Bernard J. Gersh,Timothy D. Henry,Anthony Mathur

Journal of the Society for Cardiovascular Angiography & Interventions（2023）

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摘要

•Further therapeutic options are needed for the treatment of refractory angina.•Proangiogenic growth factor therapy led to improvements in major adverse cardiac events and Canadian Cardiovascular Society class.•Larger studies are justified to look for a definitive beneficial signal.•The optimal delivery route, delivery vector, and protein type are yet to be identified.

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关键词

refractory angina,chronic myocardial ischemia,angiogenesis,gene therapy,meta-analysis

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