A metabolite specific 3D stack-of-spirals bSSFP sequence for improved bicarbonate imaging in hyperpolarized [1-13C]Pyruvate MRI

Xiaoxi Liu,Shuyu Tang,Di Cui,Robert A. Bok,Hsin-Yu Chen,Jeremy W. Gordon,Zhen J. Wang,Peder E.Z. Larson

Journal of Magnetic Resonance（2023）

引用 0|浏览0

暂无评分

摘要

•13C-bicarbonate is a crucial measure of pyruvate oxidation and TCA cycle flux.•Signal of 13C-bicarbonate can be increased with a bSSFP sequence.•Bicarbonate MS-bSSFP requires specialized RF pulse, optimized TR and 3D encoding.•Bicarbonate MS-bSSFP shows SNR improvements in preclinical, human brain and human kidney studiesMetabolite-specific bSSFP sequence has the potential to estimate T2 of HP13C metabolites.

查看译文

关键词

Hyperpolarized 13C,bSSFP,Metabolic imaging,13C-bicarbonate,SNR,Pyruvate oxidation

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要