Mechanism of the anti-liver fibrosis effect of Periplaneta americana extracts that promote apoptosis of HSC-T6 cells through the Bcl-2/Bax signaling pathway

Liping Yuan, Xiao Yang, Ying He,Yanwen Zhao,Yi Chen,Yongshou Yang,Peiyun Xiao

Journal of Asia-Pacific Entomology（2023）

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摘要

•PA-B induced HSC-T6 cell apoptosis by inhibiting proliferation.•PA-B reduced mitochondrial membrane potential.•PA-B ameliorated apoptosis-related protein expression.•PA-B (120 mg/kg) significantly alleviated CCl4-induced hepatic fibrosis injury.•PA-B reduced the aspartate aminotransferase and alanine aminotransferase levels.

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关键词

Apoptosis,Bcl-2/Bax,Hepatic fibrosis,Hepatic stellate cell,Periplaneta americana

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