Triphenylphosphonium-functionalized N-heterocyclic carbene platinum complexes [(NHC-TPP+)Pt] induce cell death of human glioblastoma cancer stem cells

Patricia Fernandez de Larrinoa,Jordan Parmentier,Antoine Kichler,Thierry Achard,Monique Dontenwill,Christel Herold-Mende,Sylvie Fournel,Benoît Frisch,Béatrice Heurtault,Stéphane Bellemin-Laponnaz

International Journal of Pharmaceutics（2023）

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摘要

•Synthesis and characterization of new NHC-Pt complexes with a TPP+ group.•Our lead compound killed efficiently glioblastoma cancer stem cells.•The addition of triphenylphosphonium onto NHC-Pt increases the production of ROS.•The TPP+–NHC-Pt complexes induce an atypical cell death on cancer stem cells.

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关键词

Glioblastoma, N-Heterocylic Carbene platinum complexes, Cytotoxicity, Mitochondria, Triphenylphosphonium moiety, Cancer stem cells

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