Comparison of scale-up strategies in twin-screw wet granulation

Marcel Franke, Thomas Riedel,Robin Meier,Carsten Schmidt,Peter Kleinebudde

International Journal of Pharmaceutics（2023）

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摘要

•Scale-based differences in granule size distributions converge after milling.•Similar granule and tablet properties were achieved during scale-up.•No practically relevant differences based on scale-up strategies.•Liquid to solid ratio has shown a higher impact than process scale-up.

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关键词

Continuous manufacturing, Twin-screw wet granulation, Continuous wet granulation, Continuous fluid bed drying, Process scaling, Scale-up

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