Chronic exposure to nitric oxide sensitizes prostate cancer cells and improved ZnO/CisPt NPs cytotoxicity and selectivity

Joana Claudio Pieretti,Bruna Moreira Freire,Giovana Marchini Armentano,Bianca de Melo Santana,Bruno Lemos Batista,Marcela Sorelli Carneiro-Ramos,Amedea Barozzi Seabra

International Journal of Pharmaceutics（2023）

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摘要

•ZnO/CisPt NPs promote a targeted and sustained release at tumor microenvironment;•GSNO chronic administration at low concentration enhances S-nitrosothiol content;•NO chronic treatment sensitizes cancer cells improving nanochemotherapy.

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关键词

Chemotherapy,Nanoparticles,Nitric oxide,S-nitrosylation,Signaling

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