Is spontaneous coronary artery dissection (SCAD) related to local anatomy and hemodynamics? An exploratory study

Panel A: Baseline coronary angiography (left) showing the target SCAD with yellow arrows pointing to the proximal end of the SCAD. Follow-up coronary angiography (right) showing the complete healing of the vessel without any coronary intervention. Panel B: The healed coronary vessel is reconstructed from the follow-up coronary angiography and vessel curvature and vessel tortuosity peaks are obtained. ‘Match’ is defined by the co-localization of high peak curvature or tortuosity hot spots (red markers) with the angiographically-defined SCAD region of interest (ROI, red arrows). Panel C: Results of the computational fluid dynamics (CFD) analysis on the three-dimensional coronary vessel reconstruction. ‘Match’ is defined by the co-localization of high time-averaged wall shear stress (TAWSS) or topological shear variation index (TSVI) hot spots (red markers) with the angiographically-defined SCAD ROI (red arrows).Unlabelled Image