Polyphyllin VII protects from breast cancer-induced osteolysis by suppressing osteoclastogenesis via c-Fos/NFATc1 signaling

Qin Yang,Jingyun Guo,Jiehuang Zheng,Yan Chen,Binhua Zou,Ruopeng Li,Zongbao Ding,Yiyuan Wang,Lihong Li,Ziye Chen,Lixia Mo,Qinghe Liang, Fengsheng Chen,Xiaojuan Li

International Immunopharmacology（2023）

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摘要

•PP7 protects against breast cancer-induced osteolysis.•PP7 suppresses MDA-MB-231 CM induced osteoclastogenesis through inhibition of c-Fos/NFATc1 signaling.•PP7 might be a safe and effective agent for treating skeletal-related events (SREs) in bone metastatic breast cancer.

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关键词

osteoclastogenesis,osteolysis,cancer-induced,c-fos

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