Methylene blue targets PHD3 expression in murine microglia to mitigate lipopolysaccharide-induced neuroinflammation and neurocognitive impairments

Guoyao Ou,Ji Che,Jing Dong,Yixu Deng,Xuliang Jiang, Yinying Sun, Zhiyong He,Wei Chen,Jun Zhang

International Immunopharmacology（2023）

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摘要

•Methylene blue (MB) attenuates microglial PHD3-dependent neuroinflammatory response;•MB reverses LPS-induced metabolic reprogramming and proinflammatory phenotype of microglia;•MB improves neurobehavioral deficits in LPS-treated mice;•Siah2/Morg1/PHD3 signaling mediates MB protecting against LPS-induced neuroinflammation.

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关键词

Methylene blue,Prolyl Hydroxylase 3,Microglia,Lipopolysaccharide,Neuroinflammation,Cognitive dysfunction

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