Focal adhesion kinase induces cardiac remodeling through NF-κB-mediated inflammatory responses in diabetic cardiomyopathy

•Chronic inflammation is involved in the development of diabetic cardiomyopathy.•FAK inhibition reduces hyperglycemia-induced cardiac inflammation and cardiac remodeling in diabetic mice.•Cardiomyocytes-derived FAK activates pro-inflammatory NF-κB signaling pathway.•FAK activates pro-inflammatory NF-κB signaling pathway via directly activating TAK1.