BMSC-derived extracellular vesicles promoted osteogenesis via Axin2 inhibition by delivering MiR-16-5p

Jiaxin Duan,Hao Li,Changyuan Wang,Jialin Yao,Yue Jin, Jianyu Zhao,Yukun Zhang,Mozhen Liu,Huijun Sun

International Immunopharmacology（2023）

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摘要

•BMSCs-derived EVs could promote osteogenic differentiation in H2O2-treated BMSCs.•miR-16-5p was enriched in BMSCs-derived EVs and promoted osteogenesis.•miR-16-5p directly targeted Axin2 and inhibited Axin2 gene expression.•miR-16-5p enriched in BMSC-derived EVs promoted osteogenesis by modulating the Axin2/Wnt/β-catenin pathway.

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