Cyclophosphamide induced intestinal injury is alleviated by blocking the TLR9/caspase3/GSDME mediated intestinal epithelium pyroptosis

International Immunopharmacology（2023）

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摘要

•CYC induces IEC-6 cell pyroptosis by activating TLR9/Caspase3/GSDME pathway.•Inhibition of pyroptosis reduces CYC-induced intestinal injury.

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关键词

Pyroptosis, GSDME, TLR9, Cyclophosphamide, Hydroxychloroquine

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