Toll-like receptor 2 deficiency alleviates acute pancreatitis by inactivating the NF-κB/NLRP3 pathway

Lingyun Li,Qiang Liu, Chenyu Le,Hongchen Zhang, Wenfei Liu,Ye Gu,Jianfeng Yang,Xiaofeng Zhang

International Immunopharmacology（2023）

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摘要

•The expression of TLR2 was increased in AP patients and AP mouse model.•TLR2 deficiency alleviated pancreatic injury in the AP mouse model.•The TLR2/NF-κB/NLRP3 pathway may be a key factor in the exacerbation of AP.

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关键词

Acute pancreatitis, TLR2, NLRP3 inflammasome, NF-xB, HMGB1

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