LncRNA MEG3 aggravates adipocyte inflammation and insulin resistance by targeting IGF2BP2 to activate TLR4/NF-κB signaling pathway

International Immunopharmacology（2023）

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摘要

•Knockdown of LncRNA MEG3 alleviates adipocyte inflammatory injury.•IGF2BP2 is an RNA binding protein for LncRNA MGE3.•Knockdown of IGF2BP2 alleviates adipocyte insulin resistance.•LncRNA MGE3 aggravates adipocyte injury by activating TLR4 pathway via upregulating IGF2BP2 expression•Knockdown of LncRNA MGE3 expression alleviates obesity in mice

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关键词

adipocyte inflammation,lncrna meg3,igf2bp2,insulin resistance

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