IL-27 enhances peripheral B cell glycolysis of rheumatoid arthritis patients via activating mTOR signaling

•B cells are essential in rheumatoid arthritis (RA) pathogenesis. But how the complex signaling network reprograms B cell metabolisms to affect the cell fate in RA remains unclear.•Glycolysis was increased significantly in RA B cells and glycolysis inhibition downregulated RA B cell proliferation, differentiation, and inflammatory actions. RA serum and IL-27 promoted B cell glycolysis, which could be obviously rescued by anti-IL-27 antibodies or mTOR inhibitor rapamycin.•Targeting IL-27 or B cell glycolysis may be an efficient therapy to ameliorate the clinical symptoms of RA.