Carboplatin ameliorates the pathogenesis of experimental autoimmune encephalomyelitis by inducing T cell apoptosis

Jie Lv,Mengyao Han,Guangyu Liu,Wei Zhuang,Chun Wang,Ling Xie, Kaidireya Saimaier, Sanxing Han,Changjie Shi,Qiuhong Hua,Ru Zhang,Changsheng Du

International Immunopharmacology（2023）

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摘要

•Carboplatin attenuates EAE and alleviates inflammatory response in CNS.•Carboplatin reduced the number of pathogenic T cells in the peripheral immune system.•Carboplatin induced apoptosis in activated T cells and MOG-specific T cells.

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关键词

experimental autoimmune encephalomyelitis,apoptosis,pathogenesis

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