The onco-embryonic antigen ROR1 is a target of chimeric antigen T cells for colorectal cancer

Shangsen Meng,Ming Li,Le Qin,Jiang Lv,Di Wu,Diwei Zheng, Heng Jia,Dongmei Chen,Qiting Wu,Youguo Long,Zhaoyang Tang,Yanlai Tang,Lihua Yang,Yao Yao,Xuequn Luo,Peng Li

International Immunopharmacology（2023）

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摘要

•ROR1 is an excellent oncoembryonic antigen in colorectal cancer tissues.•AntiROR1-CART exists effective CAR-mediated specific antitumor function targeting ROR1 in vitro and in vivo.•AntiROR1-CART fills the void in colorectal cancer treatment with ROR1 as a target of CAR-T immunotherapy.

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关键词

ROR1, CAR-T, CRC, Immunotherapy

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