L-quebrachitol extracted from industrial rubber serum: a study on its antioxidant activities and bone mineral density enhancing functions
Industrial Crops and Products(2023)
摘要
In Southeast Asia, the natural rubber (Hevea brasiliensis) industry has expanded dramatically, and throughout the production process, a sizeable portion of industrial rubber serum is treated as effluent. L-quebrachitol has been proved as a natural product abundantly present in natural rubber serum. In order to improve the utilization rate of natural rubber, a method was provided to extract L-quebrachitol from industrial rubber serum, and the yield was 0.1∼0.2%. By using mass spectrometer, Fourier transform infrared, and nuclear magnetic resonance spectroscopy, the isolated molecule was identified as L-quebrachitol. Meanwhile, there is a lack of complete research on the antioxidant capacity of L-quebrachitol, and the effect of L-quebrachitol on bone mineral density remains at the cellular level. In this work, L-quebrachitol was confirmed to have a great ability to scavenge free radicals, especially at a concentration of 0.5 mg/mL. The protective capacity of antioxidant enzymes (catalase, total glutathione peroxidase, and superoxide dismutase) and the ability to inhibit lipid peroxidation of L-quebrachitol at concentrations of 50 and 100 μg/mL was remarkable. Furthermore, animal experiment showed that L-quebrachitol at 125 mg/kg·bw can significantly reduce weight gain, increase bone mineral density and bone calcium content of ovariectomized rats. Consequently, L-quebrachitol could be used as a novel antioxidant to prevent oxidative stress-related diseases or as an agent to increase bone density to prevent osteoporosis.
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关键词
Industrial rubber serum,L-quebrachitol,Free radicals scavenging,Cell antioxidant,Postmenopausal osteoporosis
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