Carboplatin dosing in the treatment of ovarian cancer: An NRG oncology group study

Aaron M. Praiss,Austin Miller,Judith Smith,Stuart M. Lichtman,Michael Bookman,Carol Aghajanian,Paul Sabbatini,Floor Backes,David E. Cohn,Peter Argenta,Michael Friedlander,Michael J. Goodheart, David G. Mutch,David M. Gershenson,Krishnansu S. Tewari,Robert M. Wenham,Andrea E. Wahner Hendrickson,Roger B. Lee,Heidi Gray,Angeles Alvarez Secord

Gynecologic Oncology（2023）

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摘要

•The formula used to estimate CrCl affects carboplatin dosing.•Estimated creatinine clearance (CrCl) <60 mL/min (by Jelliffe) did not accurately predict adverse events.•Our data do not support a minimum threshold CrCl <60 mL/min as exclusion criteria from clinical trials.

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关键词

Carboplatin dosing,Creatinine clearance,Cockcroft-Gault formula,Jelliffe formula,Wright formula,Modification of diet in renal disease formula

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