LncRNA FAM13A-AS1, transcriptionally regulated by PHOX2B, modulates hepatocellular carcinoma chemoresistance via stabilizing PPARγ

•FAM13A-AS1 is a novel long non-coding RNA (lncRNA) that promotes the proliferation of DDP-resistant HCC cells.•FAM13A-AS1 interacts directly with Peroxisome Proliferator Activated Receptor γ (PPARγ) and stabilizes its protein through de-ubiquitination, potentially contributing to DDP resistance.•Paired Like Homeobox 2B (PHOX2B) transcriptionally regulates the expression of FAM13A-AS1 in HCC cells, providing a potential target for future therapies.•The findings of this study provide new insights into the mechanism of DDP resistance in HCC and may lead to the development of more effective treatments.