β-Cyclodextrin as a green booster for the extraction of polyphenols from blackthorn fruits: Bioactivity determination and molecular docking analysis

Blackthorn fruits are rich source of polyphenols that exert numerous biological activities. But, diverse structure and polarity of phenolic compounds limit their extractability and bioavailability. Therefore, the efficiency of a green co-solvent β-cyclodextrin was examined in boosting the blackthorn polyphenols extraction. Compared to water, as the greenest solvent, β-cyclodextrin was the most efficient in the extraction of flavonoid glycosides quercetin 3-O-glucoside and cyanidin 3-O-glucoside with the extraction rate increase of over 50 % and 40 %, respectively.