Diabetes and HIV: Protocol for a Systematic Review

Abstract Background: The HIV/AIDS challenge continues to affect millions of people worldwide. Over 77 million cases of people infected have been recorded and over 35 million of these have died. Due to availability of effective anti-retroviral therapy in the recent years, mortality due to AID-related illness has been declining; resulting in PLWH living longer. This increase in longevity, along with the adverse effects of some anti-retroviral medications has led to an increase in developing chronic diseases that are age-related, such as diabetes among PLWHIV. This makes is important to embark on a systematic review of literatures to establish the magnitude and the impact of diabetes in PLWH, hence this study.Method: Guided by the PRISMA-P 2015 checklist, a mapping of evidence from studies that are related in peer-reviewed journals that were published from 2000 to 2019 globally will be done. An electronic keyword search of Pubmed, Medline, PsycInfo and EMBASE databases will be carried out. A title screening will be followed by an independent screening of the abstracts and full texts by two reviewers. Any study that is concerned with the prevalence and/or incidence of diabetes among adults (18 years or older) persons living with HIV (PLWH), risk factors of diabetes among PLWH will also be considered. The data will be analyzed using the meta () command R software version 3.6.1Discussion: This review will chart an evidence in the literature of prevalence and incidence of diabetes among PLWH, risk factors of diabetes among PLWH and compare it with the prevalence, incidence and risk factors of diabetes among the general populace.