Does nonlinear blood-brain barrier transport matter for (lower) morphine dosing strategies?

Berfin Gülave,Divakar Budda,Mohammed AA Saleh,JG Coen van Hasselt,Elizabeth CM de Lange

European Journal of Pharmaceutical Sciences（2023）

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摘要

•Nonlinear transport affects relative morphine exposure in brainECF.•Nonlinear transport affects PK fluctuations of morphine in brainECF.•Nonlinear transport affects brainECF PK relationship of morphine and its metabolites.

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关键词

Morphine, Blood -brain barrier, Nonlinear, LeiCNS-PK3, 0

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